Ruaha is rich in wildlife diversity. Visitors can expect to see a variety of species, such as the greater and lesser kudu, and with some luck sable and roan antelopes, which can be challenging to find elsewhere. Predators such lion, leopard and cheetah are frequently sighted, whilst wild dog are resident as well. Among the birds, the park is a haven for over 570 species, including the crested barbet and ashy starling, often seen around the more arid sections of the park.
A significant portion of the park’s ecology is dependent on the Great Ruaha River. This watercourse serves as a year-round source of water for the area’s inhabitants. The river’s banks form a congregational hub for wildlife, especially during the dry season, making it an ideal location for observing the intricate interplay between predator and prey.